An internal standard for the quantification of propylthiouracil
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Unlabeled Version(s)
14069Propylthiouracil
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Propylthiouracil-d5

Item No. 30743

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-6-(propyl-2,2,3,3,3-d5)-2-thioxo-4(1H)-pyrimidinone
CAS Number
1189423-94-6
Synonyms
  • 6-n-Propylthiouracil-d5
  • PTU-d5
Molecular Formula
C7H5D5N2OS
Formula Weight
175.3
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C1NC(NC(CC([2H])([2H])C([2H])([2H])[2H])=C1)=S
InChi Code
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)/i1D3,2D2
InChi Key
KNAHARQHSZJURB-ZBJDZAJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    2.5 mg

    $382

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    Product Description

    Propylthiouracil-d5 is intended for use as an internal standard for the quantification of propylthiouracil (Item No. 14069) by GC- or LC-MS. Propylthiouracil (PTU) is a thioamide antithyroid agent.1 It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.2 Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takayama, S., Aihara, K., Onodera, T., et al. Antithyroid effects of propylthiourad and sulfamonomethoxine in rats and monkeys. Toxicol. Appl. Pharmacol. 82(2), 191-199 (1986).

    2. Drewnowski, A., and Rock, C.L. The influence of genetic taste markers on food acceptance. Am. J. Clin. Nutr. 62(3), 506-511 (1995).