Adropin Monoclonal Antibody (Clone CC1133F5)

Adropin is a 76 amino acid secreted peptide expressed in the brain, liver, and plasma and is encoded by the energy homeostasis associated gene.¹ It is highly conserved in mammals, and is involved in glucose homeostasis and lipid metabolism.¹ Plasma levels of adropin decrease with age and have been associated with metabolic disorders such as dyslipidemia and insulin resistance.² Adropin is involved in post-transcriptional activation of eNOS, the up-regulation of VEGFR2, and activation of the ERK1/2 pathway.³ Adropin’s involvement in endothelial cells results in increased proliferation and migration, and decreased permeability and apoptosis.³ Western blot detects adropin at 14-17 kDa in an over-expression cell lysate, and at 25 kDa for SUMO-tagged adropin recombinant protein.

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1. Kumar, K.G., Trevaskis, J.L., Lam, D.D., et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 8(6), 468-481 (2008).

2. Butler, A.A., Tam, C.S., Stanhope, K.L., et al. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J. Clin. Endocrinol. Metab. 97(10), 3783-3791 (2012).

3. Lovren, F., Pan, Y., Quan, A., et al. Adropin is a novel regulator of endothelial function. Circulation 122(Suppl 11), S185-S192 (2010).