A small molecule activator of PGC-1α expression
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Alternative(s)
9002449ZLN005 (hydrochloride)
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ZLN005

Item No. 14121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
CAS Number
49671-76-3
Molecular Formula
C17H18N2
Formula Weight
250.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 14 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 5 mg/ml
λmax
243, 305, 319 nm
SMILES
CC(C)(C)C(C=C1)=CC=C1C2=NC3=CC=CC=C3N2
InChi Code
InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
InChi Key
LQUNNCQSFFKSSK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $45

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    10 mg

    $81

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    25 mg

    $146

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    50 mg

    $248

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.1 Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L.N., Zhou, H.Y., Fu, Y.Y., et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 62(4), 1297-1307 (2013).