A natural inhibitor of GSK3 and CDK isoforms
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Isomer(s)
33208Isoindigo
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Indirubin

Item No. 14155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
CAS Number
479-41-4
Synonyms
  • C.I. 73200
  • Couroupitine B
  • Indigopurpurin
  • NSC 105327
Molecular Formula
C16H10N2O2
Formula Weight
262.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
241, 289, 360 nm
SMILES
O=C(C1=CC=CC=C1N/2)C2=C3C(NC4=CC=CC=C4\3)=O
InChi Code
InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-
InChi Key
CRDNMYFJWFXOCH-YPKPFQOOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 μM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 μM for both isoforms).1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferandin, Y., Bettayeb, K., Kritsanida, M., et al. 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. J. Med. Chem. 49(15), 4638-4649 (2006).

    2. Guengerich, F.P., Sorrells, J.L., Schmitt, S., et al. Generation of new protein kinase inhibitors utilizing cytochrome P450 mutant enzymes for indigoid synthesis. J. Med. Chem. 47(12), 3236-3241 (2004).

    3. McGovern, S.L., and Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. J. Med. Chem. 46(8), 1478-1483 (2003).