A selective inhibitor of p38α and p38β MAP kinase
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SD 169

Item No. 14156

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-indole-5-carboxamide
CAS Number
1670-87-7
Synonyms
  • 5-Carbamoylindole
Molecular Formula
C9H8N2O
Formula Weight
160.2
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/mlEthanol: 1.4 mg/ml
λmax
237, 276 nm
SMILES
NC(C1=CC=C(NC=C2)C2=C1)=O
InChi Code
InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
InChi Key
GQMYQEAXTITUAE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $69

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    25 mg

    $157

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).1 It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.1 SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.1 In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.1 SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Medicherla, S., Protter, A.A., Ma, J.Y., et al. Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J. Pharmacol. Exp. Ther. 318(1), 99-107 (2006).

    2. Myers, R.R., Sekiguchi, Y., Kikuchi, S., et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 184(2), 606-614 (2003).