An antiviral guanosine analog
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Labeled Version(s)
26272Acyclovir-d4
Pro-drug Form(s)
23801L-Valacyclovir (hydrochloride)
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Acyclovir

Item No. 14160

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
CAS Number
59277-89-3
Synonyms
  • ACV
  • BW 248U
  • NSC 645011
Molecular Formula
C8H11N5O3
Formula Weight
225.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 16 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
255 nm
SMILES
O=C1C2=C(N(COCCO)C=N2)N=C(N)N1
InChi Code
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChi Key
MKUXAQIIEYXACX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).1 It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.2 Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balfour, H.H., Jr. Management of cytomegalovirus disease with antiviral drugs. Rev. Infect. Dis. 12(Suppl. 7), S849-S860 (1990).

    2. Bean, B. Antiviral therapy: Current concepts and practices. Clin. Microbiol. Rev. 5(2), 146-182 (1992).

    3. Ashton, R.J., Abbott, K.H., Smith, G.M., et al. Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16. J. Antimicrob. Chemother. 34(2), 287-290 (1994).