An α-glucosidase inhibitor
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Voglibose

Item No. 14179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol
CAS Number
83480-29-9
Synonyms
  • AO-128
Molecular Formula
C10H21NO7
Formula Weight
267.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mLPBS (pH 7.2): 5 mg/mL
SMILES
O[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(O)C[C@@H]1NC(CO)CO
InChi Code
InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
InChi Key
FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $103

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    100 mg

    $153

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    500 mg

    $420

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Voglibose is an inhibitor of α-glucosidases (IC50s = 5.6, 0.11, 0.16, and 0.07 µM for human lysosomal α-glucosidase and rat maltase, isomaltase, and sucrase, respectively).1 It is selective for human α- over β-glucosidase (IC50 = >1,000 μM). Voglibose (0.2 mg/kg) decreases body weight and food intake in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuriyama, C., Kamiyama, O., Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg. Med. Chem. 16(15), 7330-7336 (2008).

    2. Goda, T., Suruga, K., Komori, A., et al. Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br. J. Nutr. 98(4), 702-710 (2007).