An inhibitor of Gli transcription
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GANT 58

Item No. 14193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4’,4’’,4’’’-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine
CAS Number
64048-12-0
Synonyms
  • NSC 75503
Molecular Formula
C24H16N4S
Formula Weight
392.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 1.1 mg/mlEthanol: 1.4 mg/ml
λmax
264, 314 nm
SMILES
C1(C2=CC=NC=C2)=C(C3=CC=NC=C3)C(C4=CC=NC=C4)=C(C5=CC=NC=C5)S1
InChi Code
InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
InChi Key
USWLOKMMUTWFMD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    GANT 58 is a Gli antagonist that inhibits Gli1-mediated transcription (EC50 = 5 μM) in a variety of cell types.1,2,3 It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting Gli1 nuclear accumulation.1 GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stanton, B.Z., and Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst. 6(1), 44-54 (2010).

    2. Joo, J., Christensen, L., Warner, K., et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One 4(10), (2009).

    3. Beauchamp, E., Bulut, G., Abaan, O., et al. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. The Journal of Biological Chemisty 284(14), 9074-9082 (2009).