A CB2 receptor agonist
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Isomer(s)
38954Dienestrol
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Magnolol

Item No. 14233

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5'-di-2-propen-1-yl-[1,1'-biphenyl]-2,2'-diol
CAS Number
528-43-8
Synonyms
  • NSC 293099
Molecular Formula
C18H18O2
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 16 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
λmax
215, 292 nm
SMILES
OC(C=CC(CC=C)=C1)=C1C2=CC(CC=C)=CC=C2O
InChi Code
InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
InChi Key
VVOAZFWZEDHOOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    Product Description

    Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rempel, V., Fuchs, A., Hinz, S., et al. Magnolia extract, magnolol, and metabolites: Activation of cannabinoid CB2 receptors and blockade of the related GPR55. ACS Med. Chem. Lett. 4(1), 41-45 (2013).