A ROCK inhibitor
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Thiazovivin

Item No. 14245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide
CAS Number
1226056-71-8
Synonyms
  • Tzv
Molecular Formula
C15H13N5OS
Formula Weight
311.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 14 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/mlEthanol: 1 mg/ml
λmax
211, 261, 300 nm
SMILES
O=C(NCC1=CC=CC=C1)C2=CSC(NC3=CC=NC=N3)=N2
InChi Code
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChi Key
DOBKQCZBPPCLEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $47

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactions necessary for maintaining human embryonic stem cell survival and self-renewal.1 Thiazovivin is a selective, cell-permeable small molecule that inhibits ROCK activity at a concentration 2 µM.1 It promotes the survival of induced pluripotent stem cells and improves their reprogramming efficiency from human fibroblasts more than 200 fold when used in combination with the ALK5 inhibitor SB 431542 (Item No. 13031) and the MEK inhibitor PD0325091 (Item No. 13034).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y., Zhu, X., Hahm, H.S., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 107(18), 8129-8134 (2010).

    2. Lin, T., Ambasudhan, R., Yuan, X., et al. A chemical platform for improved induction of human iPSCs. Nat. Methods 6(11), 805-808 (2009).

    Product Citations

    Abraham, E., Kostina, A., Volmert, B., et al. A retinoic acid: YAP1 signaling axis controls atrial lineage commitment. Cell Rep. 44(5), 115687 (2025).

    Sorge, M., Savoré, G., Gallo, A., et al. An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress. EMBO Mol. Med. 16(10), 2450-2484 (2024).