FFAR4 (GPR120) (C-Term) Polyclonal Antibody

G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages.¹ The activation of GPR120 results in elevated Ca²⁺ and activation of the ERK cascade.¹ ω-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.² The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis.¹ The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.

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1. Katsuma, S., Hatae, N., Yano, T., et al. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. The Journal of Biological Chemisty 280(20), 19507-19515 (2005).

2. Oh, D.Y., Talukdar, S., Bae, E.J., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effects. Cell 142(5), 687-698 (2010).