A potent calmodulin antagonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

W-13 (hydrochloride)

Item No. 14277

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide, monohydrochloride
CAS Number
88519-57-7
Molecular Formula
C14H17ClN2O2S • HCl
Formula Weight
349.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 14 mg/mlEthanol: 0.3 mg/mlWater: 30 mg/ml
λmax
234, 283 nm
SMILES
ClC1=C2C(C=C(S(NCCCCN)(=O)=O)C=C2)=CC=C1.Cl
InChi Code
InChI=1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
InChi Key
QKAALLVQBOLELJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $106

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    10 mg

    $161

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    Product Description

    W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katayama, N., Nishikawa, M., Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990).

    2. Tebar, F., Villalonga, P., Sorkina, T., et al. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Mol. Biol. Cell 13(6), 2057-2068 (2002).

    3. Sengupta, P., Ruano, M.J., Tebar, F., et al. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: Dual effect of W-13 on epidermal growth factor receptor activation. The Journal of Biological Chemisty 282(11), 8474-8486 (2007).