A prodrug form of R-99224
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Labeled Version(s)
28160Prasugrel-d5
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Prasugrel

Item No. 14278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-ethanone
CAS Number
150322-43-3
Synonyms
  • CS 747
  • LY640315
Molecular Formula
C20H20FNO3S
Formula Weight
373.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: Slightly solublePBS (pH 7.2): 0.25 mg/ml
SMILES
CC(OC1=CC2=C(S1)CCN(C(C(C3CC3)=O)C4=CC=CC=C4F)C2)=O
InChi Code
InChI=1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3
InChi Key
DTGLZDAWLRGWQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $37

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    100 mg

    $70

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    250 mg

    $163

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    500 mg

    $289

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    Product Description

    Prasugrel is a prodrug form of the platelet purinergic P2Y12 receptor antagonist R-99224.1 Prasugrel (0.3 and 3 mg/kg) inhibits ex vivo washed platelet aggregation in rat platelet rich-plasma.2 In vivo, prasugrel prevents thrombus formation (ED50 = 0.68 mg/kg) and increases tail bleeding time in rats. Formulations containing prasugrel have been used in the prevention of blood clots.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sugidachi, A., Asai, F., Yoneda, K., et al. Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type Gi-linked P2T antagonist, CS-747. Br. J. Pharmacol. 132(1), 47-54 (2001).

    2. Sugidachi, A., Asai, F., Ogawa, T., et al. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br. J. Pharmacol. 129(7), 1439-1446 (2000).