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JWH 081 N-pentanoic acid metabolite

Item No. 14353

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-methoxy-1-naphthalenyl)carbonyl]-1H-indole-1-pentanoic acid
CAS Number
1537889-08-9
Molecular Formula
C25H23NO4
Formula Weight
401.5
Purity
≥98%
Formulation
A solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/ml
λmax
212, 315 nm
SMILES
O=C(C1=CC=C(OC)C2=C1C=CC=C2)C3=CN(CCCCC(O)=O)C4=C3C=CC=C4
InChi Code
InChI=1S/C25H23NO4/c1-30-23-14-13-20(17-8-2-3-10-19(17)23)25(29)21-16-26(15-7-6-12-24(27)28)22-11-5-4-9-18(21)22/h2-5,8-11,13-14,16H,6-7,12,15H2,1H3,(H,27,28)
InChi Key
WPMGCTPEKHVDAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 081 (Item No. 10579) is a cannabimimetic indole related to JWH 015 (Item No. 10009018) and JWH 018 (Item No. 10900) that shows preference for the central cannabinoid (CB1) receptor (Ki = 1.2 nM) over the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM).1,2 JWH 081 N-pentanoic acid metabolite is an expected metabolite of JWH 081 that would be detectable both in serum and in urine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60(2), 133-140 (2000).

    2. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorg. Med. Chem. 13(1), 89-112 (2005).