A typical antipsychotic
Related Products
Active Metabolite(s)
31370Mesoridazine
Labeled Version(s)
30239Thioridazine-d3 (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thioridazine (hydrochloride)

Item No. 14400

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine, monohydrochloride
CAS Number
130-61-0
Synonyms
  • Aldazine
  • NSC 186060
Molecular Formula
C21H26N2S2 • HCl
Formula Weight
407.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
230, 263, 316 nm
SMILES
CSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCC4N(C)CCCC4.Cl
InChi Code
InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
InChi Key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $36

    Add

    5 g

    $73

    Add

    10 g

    $132

    Add

    25 g

    $294

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Thioridazine is a typical antipsychotic.1 It binds to dopamine D2, histamine H1, M3 muscarinic, and α1- and α2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.2 It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.3 Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).

    2. Tschanz, J.T., and Rebec, G.V. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol. Biochem. Behav. 31(3), 519-522 (1988).

    3. Ishida-Tokuda, K., Ohno, Y., Sakamoto, H., et al. Evaluation of perospirone (SM-9018), a novel serotonin-2 and dopamine-2 receptor antagonist, and other antipsychotics in the conditioned fear stress-induced freezing behavior model in rats. Jpn. J. Pharmacol. 72(2), 119-126 (1996).

    4. Amaral, L. Thioridazine: An old neuroleptic effective against totally drug resistant tuberculosis. Acta Med. Port. 25(2), 118-121 (2012).

    Product Citations

    Huff, H.C., Vasan, A., Roy, P., et al. Differential interactions of selected phytocannabinoids with human CYP2D6 polymorphisms. Biochemistry (2021).