An internal standard for the quantification of thioridazine
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Unlabeled Version(s)
14400Thioridazine (hydrochloride)
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Thioridazine-d3 (hydrochloride)

Item No. 30239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-(2-(1-(methyl-d3)piperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine, monohydrochloride
CAS Number
1189928-36-6
Synonyms
  • Aldazine-d3
Molecular Formula
C21H23D3N2S2 • HCl
Formula Weight
410.1
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
CSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCC4N(C([2H])([2H])[2H])CCCC4.Cl
InChi Code
InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H/i1D3;
InChi Key
NZFNXWQNBYZDAQ-NIIDSAIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $250

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    Product Description

    Thioridazine-d3 is intended for use as an internal standard for the quantification of thioridazine (Item No. 14400) by GC- or LC-MS. Thioridazine is a typical antipsychotic.1 It binds to dopamine D2, histamine H1, M3 muscarinic, and α1- and α2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats.2 It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg.3 Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).

    2. Tschanz, J.T., and Rebec, G.V. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol. Biochem. Behav. 31(3), 519-522 (1988).

    3. Ishida-Tokuda, K., Ohno, Y., Sakamoto, H., et al. Evaluation of perospirone (SM-9018), a novel serotonin-2 and dopamine-2 receptor antagonist, and other antipsychotics in the conditioned fear stress-induced freezing behavior model in rats. Jpn. J. Pharmacol. 72(2), 119-126 (1996).

    4. Amaral, L. Thioridazine: An old neuroleptic effective against totally drug resistant tuberculosis. Acta Med. Port. 25(2), 118-121 (2012).