A cell-permeable, cAMP analog
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Bucladesine (sodium salt)

Item No. 14408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine, monosodium salt
CAS Number
16980-89-5
Synonyms
  • DC 2797
Molecular Formula
C18H23N5O8P • Na
Formula Weight
491.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
211, 271 nm
SMILES
O=P1([O-])OC[C@H]2O[C@@H](N3C4=NC=NC(NC(CCC)=O)=C4N=C3)[C@H](OC(CCC)=O)[C@@H]2O1.[Na+]
InChi Code
InChI=1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChi Key
KRBZRVBLIUDQNG-JBVYASIDSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $50

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    50 mg

    $95

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    100 mg

    $139

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    250 mg

    $297

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    Product Description

    Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiesterase inhibitor.1,2 Because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions, bucladesine is widely used in a variety of research applications. This product is also available as part of Cayman's Astrocyte Reprogramming Reagent Kit (DFICBY) (Item No. 502887).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bartsch, M., Zorn-Kruppa, M., Kühl, N., et al. Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells. Biol. Chem. 384(9), 1321-1326 (2003).

    2. Rundfeldt, C., Steckel, H., Sörensen, T., et al. The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch. Dermatol. Res. 304(4), 313-317 (2012).