A cell-permeable, cAMP analog
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14408Bucladesine (sodium salt)
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Bucladesine (sodium salt) Ancillary Material

Item No. 44786

Product Insert (PDF)
Technical Information
Formal Name
N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine, monosodium salt
CAS Number
16980-89-5
Synonyms
  • DC 2797
  • Dibutyryl-cAMP
  • Dibutyryl-Cyclic AMP
Molecular Formula
C18H23N5O8P • Na
Formula Weight
491.4
Purity
≥98%
Formulation
An amorphous solid
SMILES
O=P1([O-])OC[C@H]2O[C@@H](N3C4=NC=NC(NC(CCC)=O)=C4N=C3)[C@H](OC(CCC)=O)[C@@H]2O1.[Na+]
InChi Code
InChI=1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChi Key
KRBZRVBLIUDQNG-JBVYASIDSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    10 mg

    $189

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    Product Description

    Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiesterase inhibitor.1,2 Because it mimics cAMP, bucladesine can induce normal physiological responses when added to cells. Bucladesine (sodium salt) Ancillary Material is intended for use in cell, gene, and tissue engineering applications.

    This product has been tested in accordance with GMP principles and meets the expectations for clinical cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bartsch, M., Zorn-Kruppa, M., Kühl, N., et al. Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells. Biol. Chem. 384(9), 1321-1326 (2003).

    2. Rundfeldt, C., Steckel, H., Sörensen, T., et al. The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch. Dermatol. Res. 304(4), 313-317 (2012).

    3.  <1043> Ancillary materials for cell, gene, and tissue-engineered products. (2025).