An indoleamine neurohormone that entrains circadian rhythms
Related Products
Active Metabolite(s)
34688AMK (hydrochloride)
Analytical Standard(s)
42524Melatonin 42564Melatonin (CRM)
Labeled Version(s)
22291Melatonin-d4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Melatonin

Item No. 14427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-acetamide
CAS Number
73-31-4
Synonyms
  • N-Acetyl-5-methoxytryptamine
  • 5-Methoxy-N-acetyltryptamine
  • NSC 56423
  • NSC 113928
Molecular Formula
C13H16N2O2
Formula Weight
232.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
224, 279 nm
SMILES
COC1=CC=C(NC=C2CCNC(C)=O)C2=C1
InChi Code
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChi Key
DRLFMBDRBRZALE-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 g

    $39

    Add

    10 g

    $74

    Add

    25 g

    $154

    Add

    100 g

    $578

    Add
    Product Description

    Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.1 Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.1 Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.2,3 Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boutin, J.A., Audinot, V., Ferry, G., et al. Molecular tools to study melatonin pathways and actions. Trends Pharmacol. Sci. 26(8), 412-419 (2005).

    2. Reiter, R.J., Tan, D.X., Manchester, L.C., et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem. Biophys. 34(2), 237-256 (2001).

    3. Reiter, R.J., Tang, L., Garcia, J.J., et al. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 60(25), 2255-2271 (1997).