An internal standard for the quantification of melatonin
Related Products
Unlabeled Version(s)
14427Melatonin
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Melatonin-d4

Item No. 22291

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(5-methoxy-1H-indol-3-yl)ethyl-1,1,2,2-d4]-acetamide
CAS Number
66521-38-8
Synonyms
  • N-Acetyl-5-methoxytryptamine-d4
  • 5-Methoxy-N-acetyltryptamine-d4
Molecular Formula
C13H12D4N2O2
Formula Weight
236.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
225, 280 nm
SMILES
COC1=CC=C(NC=C2C([2H])([2H])C([2H])([2H])NC(C)=O)C2=C1
InChi Code
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)/i5D2,6D2
InChi Key
DRLFMBDRBRZALE-NZLXMSDQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $95

    Add

    1 mg

    $161

    Add

    5 mg

    $473

    Add
    Product Description

    Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.1 Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.1 Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.2,3 Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boutin, J.A., Audinot, V., Ferry, G., et al. Molecular tools to study melatonin pathways and actions. Trends Pharmacol. Sci. 26(8), 412-419 (2005).

    2. Reiter, R.J., Tan, D.X., Manchester, L.C., et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem. Biophys. 34(2), 237-256 (2001).

    3. Reiter, R.J., Tang, L., Garcia, J.J., et al. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 60(25), 2255-2271 (1997).