A PTEN inhibitor
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bpV(HOpic) (potassium salt)

Item No. 14433

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5-hydroxy-2-pyridinecarboxylato-κN1,κO2)oxodiperoxy-vanadate(2-), dipotassium
CAS Number
722494-26-0
Synonyms
  • Bisperoxovanadium(HOpic)
Molecular Formula
C6H4NO8V • 2K
Formula Weight
347.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 4 mg/mlWater: 4 mg/ml
SMILES
OC1=CC=C2[N]([V+3]34([O-]C2=O)([O-][O-]3)([O-][O-]4)=O)=C1.[K+].[K+]
InChi Code
InChI=1S/C6H5NO3.2K.2O2.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;/h1-3,8H,(H,9,10);;;;;;/q;2*+1;2*-2;;+3/p-1
InChi Key
IZLHQXYPQCZJAG-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    25 mg

    $317

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    Product Description

    bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM).1 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 4.9 μM), and PTP-1βB (IC50 = 25.3 μM).1 At 15 μM, bpV(HOpic) has been shown to protect against stimulated ischemia-reperfusion injury in vitro by decreasing apoptosis and improving cell viability through the upregulation of the PI3K/Akt/eNOS/ERK prosurvival pathway.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, A.C., Byrne, R.D., Vilar, R., et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 566(1-3), 35-38 (2004).

    2. Keyes, K.T., Xu, J., Long, B., et al. Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. Am. J. Physiol. Heart Circ. Physiol. 298(4), H1198-H1208 (2010).