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Phloretin

Item № 14452
CAS № 60-82-2
Purity ≥98%
product image
                (CAS 60-82-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     250 mg $33.00 0.00
     500 mg $63.00 0.00
     1 g $99.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • NSC 407292
  • RJC 02792

Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane.1 Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM).2,3

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Technical Information
Formal Name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
CAS Number
60-82-2
Synonyms
  • NSC 407292
  • RJC 02792
Molecular Formula
C15H14O5
Formula Weight
274.3
Purity
≥98%
Formulation
A crystalline solid
λmax
225, 287 nm
SMILES
OC1=CC=C(CCC(C2=C(O)C=C(O)C=C2O)=O)C=C1
InChI Code
InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChI Key
VGEREEWJJVICBM-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Bröer, S., Bröer, A., Schneider, H.P., et al. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes Biochemistry Journal 341, 529-535 (1999).

2. Wielert-Badt, S., Lin, J.T., Lorenz, M., et al. Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis J.Med.Chem 43(9), 1692-1698 (2000).

3. Gupte, A., and Buolamwini, J.K. Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors Bioorganic & Medicinal Chemistry Letters 19(3), 917-921 (2009).

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