A natural inhibitor of various transporters
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Metabolite(s)
363894-Hydroxyphenylpropionylglycine
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Phloretin

Item No. 14452

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
CAS Number
60-82-2
Synonyms
  • NSC 407292
  • RJC 02792
Molecular Formula
C15H14O5
Formula Weight
274.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
225, 287 nm
SMILES
OC1=CC=C(CCC(C2=C(O)C=C(O)C=C2O)=O)C=C1
InChi Code
InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChi Key
VGEREEWJJVICBM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane.1 Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bröer, S., Bröer, A., Schneider, H.P., et al. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem. J. 341(Pt 3), 529-535 (1999).

    2. Wielert-Badt, S., Lin, J.T., Lorenz, M., et al. Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis. J. Med. Chem. 43(9), 1692-1698 (2000).

    3. Gupte, A., and Buolamwini, J.K. Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg. Med. Chem. Lett. 19(3), 917-921 (2009).