A metabolite of tyrosine and phloretin
Related Products
Isomer(s)
36667E4CPG 34345N-Acetyl-L-tyrosine
Parent Compound(s)
14452Phloretin
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4-Hydroxyphenylpropionylglycine

Item No. 36389

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(4-hydroxyphenyl)-1-oxopropyl]-glycine
CAS Number
3850-43-9
Synonyms
  • Phloretic Acid Glycine Conjugate
  • Phloretylglycine
  • 4-hydroxy PPG
Molecular Formula
C11H13NO4
Formula Weight
223.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/ml
λmax
226 nm
SMILES
O=C(CNC(CCC1=CC=C(C=C1)O)=O)O
InChi Code
InChI=1S/C11H13NO4/c13-9-4-1-8(2-5-9)3-6-10(14)12-7-11(15)16/h1-2,4-5,13H,3,6-7H2,(H,12,14)(H,15,16)
InChi Key
KPKFTTASECYTCL-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $413

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    10 mg

    $783

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    25 mg

    $1,630

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    Product Description

    4-Hydroxyphenylpropionylglycine is a metabolite of the conditionally essential amino acid tyrosine.1 It is formed from tyrosine via aromatic amino acid aminotransferase, tyrosine aminotransferase, and gut microbiota, followed by glycine conjugation. 4-Hydroxyphenylpropionylglycine is also a metabolite of the phenol phloretin (Item No. 14452).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anesi, A., Berding, K., Clarke, G., et al. Metabolomic workflow for the accurate and high-throughput exploration of the pathways of tryptophan, tyrosine, phenylalanine, and branched-chain amino acids in human biofluids. J. Proteome Res. 21(5), 1262-1275 (2022).

    2. Monge, P., Solheim, E., and Scheline, R.R. Dihydrochalcone metabolism in the rat: Phloretin. Xenobiotica 14(2), 917-924 (1984).