An isatin sulfonamide-based inhibitor of caspase-3 and caspase-7
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Isomer(s)
45465MMPSI
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Caspase-3/7 Inhibitor I

Item No. 14464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2,3-dione
CAS Number
1110670-49-9
Molecular Formula
C14H16N2O5S
Formula Weight
324.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/mlMethanol: 10 mg/ml
SMILES
O=C(C1=CC(S(N2CCCC2COC)(=O)=O)=CC=C1N3)C3=O
InChi Code
InChI=1S/C14H16N2O5S/c1-21-8-9-3-2-6-16(9)22(19,20)10-4-5-12-11(7-10)13(17)14(18)15-12/h4-5,7,9H,2-3,6,8H2,1H3,(H,15,17,18)
InChi Key
SLQMNVJNDYLJSF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $129

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    5 mg

    $415

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    Product Description

    Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM).1 It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 μM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM).1,2 Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM).2 The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, D., Long, S.A., Adams, J.L., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. The Journal of Biological Chemisty 275(21), 16007-16014 (2000).

    2. Lee, D., Long, S.A., Murray, J.H., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J. Med. Chem. 44(12), 2015-2026 (2001).