An inhibitor of caspase-3 and caspase-7
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Isomer(s)
14464Caspase-3/7 Inhibitor I
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MMPSI

Item No. 45465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[(2S)-2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2,3-dione
CAS Number
220509-74-0
Synonyms
  • Caspase-3/7 Inhibitor I​
Molecular Formula
C14H16N2O5S
Formula Weight
324.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C1C2=CC(S(=O)(N3[C@H](COC)CCC3)=O)=CC=C2NC1=O
InChi Code
InChI=1S/C14H16N2O5S/c1-21-8-9-3-2-6-16(9)22(19,20)10-4-5-12-11(7-10)13(17)14(18)15-12/h4-5,7,9H,2-3,6,8H2,1H3,(H,15,17,18)/t9-/m0/s1
InChi Key
SLQMNVJNDYLJSF-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $125

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    5 mg

    $375

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    10 mg

    $500

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    25 mg

    $625

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    Product Description

    MMPSI inhibits caspase-3 and caspase-7 in a cell-free assay (IC50s = 0.085 and 1.3 µM, respectively).1 It is selective for caspase-3 and caspase-7 over caspase-1, -6, and -8 in a cell-free assay (IC50s = >15 µM). MMPSI reduces ischemia-reperfusion injury-induced apoptosis in H9c2 rat cardiomyocytes (IC50 = 0.5 µM) and spontaneous apoptosis in adult rabbit cardiomyocyte isolates (IC50 = 1.5 µM).2 It reduces infarct size in an isolated rabbit heart model of ischemia-reperfusion injury when used at concentrations of 0.1, 1, and 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kopka, K., Faust, A., Keul, P., et al. 5-Pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J. Med. Chem. 49(23), 6704-6715 (2006).

    2. Chapman, J.G., Magee, W.P., Stukenbrok, H.A., et al. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur. J. Pharmacol. 456(1-3), 59-68 (2002).