A selective FAAH inhibitor
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JNJ-1661010

Item No. 14497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
CAS Number
681136-29-8
Molecular Formula
C19H19N5OS
Formula Weight
365.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 20 mg/mlEthanol: 1.5 mg/ml
λmax
245 nm
SMILES
O=C(NC1=CC=CC=C1)N2CCN(C3=NC(C4=CC=CC=C4)=NS3)CC2
InChi Code
InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChi Key
BHBOSTKQCZEAJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $81

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    10 mg

    $121

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    25 mg

    $218

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    50 mg

    $395

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    Product Description

    JNJ-1661010 is a selective inhibitor of FAAH (IC50s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier.1 At 20 mg/kg, JNJ-1661010 has been shown to elevate levels of AEA in rat brain.1 This compound has been used to examine the contribution of endocannabinoid signaling in experimental fibrosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keith, J.M., Apodaca, R., Xiao, W., et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg. Med. Chem. Lett. 18(17), 4838-4843 (2008).

    2. Palumbo-Zerr, K., Horn, A., Distler, A., et al. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Ann. Rheum. Dis. 71, 2051-2054 (2012).