An inhibitor of integrin-ligand interactions
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RGD Peptide (trifluoroacetate salt)

Item No. 14501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-arginylglycyl-L-α-aspartyl-L-asparaginyl-L-proline, trifluoroacetate salt
Synonyms
  • GRGDNP
  • H-Gly-Arg-Gly-Asp-Asn-Pro-OH
Molecular Formula
C23H38N10O10 • XCF3COOH
Formula Weight
614.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 0.3 mg/ml
SMILES
NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C23H38N10O10.C2HF3O2/c24-9-16(35)30-11(3-1-5-28-23(26)27)19(39)29-10-17(36)31-12(8-18(37)38)20(40)32-13(7-15(25)34)21(41)33-6-2-4-14(33)22(42)43;3-2(4,5)1(6)7/h11-14H,1-10,24H2,(H2,25,34)(H,29,39)(H,30,35)(H,31,36)(H,32,40)(H,37,38)(H,42,43)(H4,26,27,28);(H,6,7)/t11-,12-,13-,14-;/m0./s1
InChi Key
RSZWQCVQZWXDRF-ZMNOQRQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $152

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    10 mg

    $263

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    25 mg

    $561

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    Product Description

    RGD peptide is a synthetic compound made up of the arginine-glycine-aspartate motif that has been extensively used to inhibit integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.1 RGD peptide has also been shown to directly induce apoptosis, independent of integrin-mediated cell clustering or signals, by initiating conformational changes that enhance pro-caspase-3 activation and autoprocessing.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruoslahti, E., and Öbrink, B. Common principles in cell adhesion. Exp. Cell Res. 227(1), 1-11 (1996).

    2. Buckley, C.D., Pilling, D., Henriquez, N.V., et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature 397(6719), 534-539 (1999).

    3. Adderley, S.R., and Fitzgerald, D.J. Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation. The Journal of Biological Chemisty 275(8), 5760-5766 (2000).