A non-selective P2-purinoceptor antagonist
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PPADS (sodium salt)

Item No. 14537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic acid, tetrasodium salt
CAS Number
192575-19-2
Synonyms
  • Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid
Molecular Formula
C14H10N3O12PS2 • 4Na
Formula Weight
599.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Slightly soluble
λmax
363, 482 nm
SMILES
[H]C(C1=C(COP([O-])([O-])=O)C(/N=N/C2=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C2)=NC(C)=C1O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4/b17-16+;;;;
InChi Key
KURWUCJJNVPCHT-PGXCWKBOSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    50 mg

    $202

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    250 mg

    $876

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    Product Description

    PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors.1 PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lambrecht, G., Friebe, T., Grimm, U., et al. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol. 217(2-3), 217-219 (1992).

    2. Lämmer, A.B., Beck, A., Grummich, B., et al. The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. PLoS One 6(5), (2011).