An adenylyl cyclase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MDL 12330A (hydrochloride)

Item No. 14559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-N-[(1R,2R)-2-phenylcyclopentyl]-azacyclotridec-1-en-2-amine, monohydrochloride
CAS Number
40297-09-4
Synonyms
  • RMI 12330A
Molecular Formula
C23H36N2 • HCl
Formula Weight
377.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlEthanol: 1 mg/ml
λmax
210 nm
SMILES
C1(/N[C@@H]2[C@H](C3=CC=CC=C3)CCC2)=N\CCCCCCCCCCC1.Cl
InChi Code
InChI=1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
InChi Key
CKOPQUCSDBVAQG-VROPFNGYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    10 mg

    $134

    Add

    25 mg

    $315

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    MDL 12330A is an adenylyl cyclase inhibitor that can also inhibit cAMP and cGMP phosphodiesterases and block slow extracellular and store-operated Ca2+ entry into cells. It is widely used to investigate the role of the adenylyl cyclase/cAMP signaling pathway. MDL 12330A has also been reported to block voltage-dependent K+ channels, extend action potential duration, and enhance insulin secretion in pancreatic β-cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Guo, Q., Gao, J., et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K+ channels in pancreatic beta cells. PLoS One 8(10), e77934 (2013).