An adenylyl cyclase inhibitor
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MDL 12330A (hydrochloride)

Item No. 14559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-N-[(1R,2R)-2-phenylcyclopentyl]-azacyclotridec-1-en-2-amine, monohydrochloride
CAS Number
40297-09-4
Synonyms
  • RMI 12330A
Molecular Formula
C23H36N2 • HCl
Formula Weight
377.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlEthanol: 1 mg/ml
λmax
210 nm
SMILES
C1(/N[C@@H]2[C@H](C3=CC=CC=C3)CCC2)=N\CCCCCCCCCCC1.Cl
InChi Code
InChI=1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
InChi Key
CKOPQUCSDBVAQG-VROPFNGYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $315

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    Cayman Chemical
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    Product Description

    MDL 12330A is an adenylyl cyclase inhibitor that can also inhibit cAMP and cGMP phosphodiesterases and block slow extracellular and store-operated Ca2+ entry into cells. It is widely used to investigate the role of the adenylyl cyclase/cAMP signaling pathway. MDL 12330A has also been reported to block voltage-dependent K+ channels, extend action potential duration, and enhance insulin secretion in pancreatic β-cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Guo, Q., Gao, J., et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K+ channels in pancreatic beta cells. PLoS One 8(10), e77934 (2013).