An excitatory neurotransmitter

Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC Questionnaire Download WB Questionnaire

First Name

Last Name

Institution

Country

State

Telephone (optional)

Product Name (optional)

Catalog Number (optional)

Batch Number (optional)

Message(0 / 2000)

Add an attachment (max size ~5mb) (optional)

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Small Molecule Modulators

Ion Channel Modulators

Activators

Research Area

(R,S)-AMPA (hydrate)

Name: (R,S)-AMPA (hydrate)
Brand: -

Item No. 14571

(R,S)-AMPA (hydrate) (α-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid, hydrate

Synonyms

α-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid

Molecular Formula

C₇H₁₀N₂O₄ • XH₂O

Formula Weight

186.2

Purity

≥95%

Formulation

A solid

Solubility(Learn about Variance in Solubility)

Water: 10 mM

λ_max

218 nm

SMILES

OC1=NOC(C)=C1CC(N)C(O)=O.O

InChi Code

InChI=1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2

InChi Key

HFISYNCCKQHIAM-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

5 mg

$138

Add

10 mg

$248

Add

25 mg

$516

Add

50 mg

$895

Add

Product Description

AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission.^1,2 Because AMPA does not interfere with binding sites for kainic acid (Item No. 78050) or NMDA (Item No. 14581), it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Scannevin, R.H., and Huganir, R.L. Postsynaptic organization and regulation of excitatory synapses. Nat. Rev. Neurosci. 1(2), 133-141 (2000).

2. Gouaux, E. Structure and function of AMPA receptors. J. Physiol. 554(2), 249-253 (2004).

Product Citations

Zhu, J., Lee, K.Y., Jewett, K.A., et al. Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet. 13(2), e1006634 (2017).

Cart Subtotal:$0