An antagonist of the muscarinic M3 receptor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

4-DAMP

Item No. 14574

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide
CAS Number
1952-15-4
Synonyms
  • 4-Diphenylacetoxy-N-methyl-piperidine methiodide
Molecular Formula
C21H26NO2 • I
Formula Weight
451.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mM
SMILES
O=C(OC1CC[N+](C)(C)CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.[I-]
InChi Code
InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
InChi Key
WWJHRSCUAQPFQO-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $46

    Add

    50 mg

    $81

    Add

    100 mg

    $125

    Add
    Product Description

    4-DAMP is a potent antagonist of the muscarinic M3 receptor (pKi = 9.3).1,2,3 It is routinely used to study the regulation and functions of the M3 receptor.4,5 4-DAMP also has a high affinity for the closely-related M5 receptor (pKi = 8.9).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barlow, R.B., and Shepherd, M.K. A search for selective antagonists at M2 muscarinic receptors. Br. J. Pharmacol. 85(2), 427-435 (1985).

    2. Barlow, R.B., and Kitchen, R. The actions of some esters of 4-hydroxyquinuclidine on guinea-pig ileum, artia and rat fundus strip. Br. J. Pharmacol. 77(3), 549-557 (1982).

    3. Watson, N., Daniels, D.V., Ford, A.P.D.W., et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br. J. Pharmacol. 127(2), 590-596 (1999).

    4. Joo, M.C., Kim, Y.S., Choi, E.S., et al. Changes in the muscarinic receptors on the colonic smooth muscles of rats with spinal cord injury. Ann.Rehabil.Med. 35(5), 589-598 (2011).

    5. Lee, B.H., Gauna, A.E., Perez, G., et al. Autoantibodies against muscarinic type 3 receptor in Sjögren’s syndrome inhibit aquaporin 5 trafficking. PLoS One 8(1), (2013).