An antagonist of the muscarinic M3 receptor
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4-DAMP

Item No. 14574

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide
CAS Number
1952-15-4
Synonyms
  • 4-Diphenylacetoxy-N-methyl-piperidine methiodide
Molecular Formula
C21H26NO2 • I
Formula Weight
451.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mM
SMILES
O=C(OC1CC[N+](C)(C)CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.[I-]
InChi Code
InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
InChi Key
WWJHRSCUAQPFQO-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $46

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    50 mg

    $81

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    100 mg

    $125

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    Product Description

    4-DAMP is a potent antagonist of the muscarinic M3 receptor (pKi = 9.3).1,2,3 It is routinely used to study the regulation and functions of the M3 receptor.4,5 4-DAMP also has a high affinity for the closely-related M5 receptor (pKi = 8.9).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barlow, R.B., and Shepherd, M.K. A search for selective antagonists at M2 muscarinic receptors. Br. J. Pharmacol. 85(2), 427-435 (1985).

    2. Barlow, R.B., and Kitchen, R. The actions of some esters of 4-hydroxyquinuclidine on guinea-pig ileum, artia and rat fundus strip. Br. J. Pharmacol. 77(3), 549-557 (1982).

    3. Watson, N., Daniels, D.V., Ford, A.P.D.W., et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br. J. Pharmacol. 127(2), 590-596 (1999).

    4. Joo, M.C., Kim, Y.S., Choi, E.S., et al. Changes in the muscarinic receptors on the colonic smooth muscles of rats with spinal cord injury. Ann.Rehabil.Med. 35(5), 589-598 (2011).

    5. Lee, B.H., Gauna, A.E., Perez, G., et al. Autoantibodies against muscarinic type 3 receptor in Sjögren’s syndrome inhibit aquaporin 5 trafficking. PLoS One 8(1), (2013).