A selective inhibitor of cyclin-dependent kinases
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Purvalanol A

Item No. 14579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
CAS Number
212844-53-6
Synonyms
  • NG 60
Molecular Formula
C19H25ClN6O
Formula Weight
388.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
λmax
216, 262, 314 nm
SMILES
CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1
InChi Code
InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChi Key
PMXCMJLOPOFPBT-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    50 mg

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    Product Description

    Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.1,2 Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.3 At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281(5376), 533-538 (1998).

    2. Bain, J., McLauchlan, H., Elliot, M., et al. The specificities of protein kinase inhibitors: An update. Biochem. J. 371(Pt. 1), 199-204 (2003).

    3. Villerbu, N., Gaben, A.M., Redeuilh, G., et al. Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities. Int. J. Cancer 97, 761-769 (2002).

    4. Hikita, T., Oneyama, C., and Okada, M. Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. Genes Cells 15, 1051-1062 (2010).