An inhibitor of the CK1 isoforms CK1ε and CK1δ
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PF-670462 (hydrochloride)

Item No. 14588

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride
CAS Number
950912-80-8
Molecular Formula
C19H20FN5 • 2HCl
Formula Weight
410.3
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
236, 322 nm
SMILES
NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.Cl.Cl
InChi Code
InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChi Key
PSNKGVAXBSAHCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $183

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    50 mg

    $634

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    Product Description

    PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively).1 It less effectively inhibits a wide variety of related or common kinases.1 Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals.1,2 It also blocks the locomotor response to amphetamines in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Badura, L., Swanson, T., Adamowicz, W., et al. An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions. J. Pharmacol. Exp. Ther. 322(2), 730-738 (2007).

    2. Storz, S.S., Tovin, A., Mracek, P., et al. Casein kinase 1δ activity: A key element in the zebrafish circadiam timing system. PLoS One 8(1), 1-10 (2013).

    3. Bryant, C.D., Graham, M.E., Distler, M.G., et al. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology (Berl) 203(4), 703-711 (2009).