A membrane-permeable, UV-light excitable form of Fura-2
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Alternative(s)
34993Fura-2 Leakage Resistant AM
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Fura-2 AM

Item No. 14591

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid, (acetyloxy)methyl ester
CAS Number
108964-32-5
Synonyms
  • Fura-2 Acetoxymethyl ester
Molecular Formula
C44H47N3O24
Formula Weight
1001.9
Purity
≥95%
Emission
510 nm
Excitation
340 and 380 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlEthanol: Slightly soluble
SMILES
O=C(OCOC(C)=O)CN(C1=CC2=C(C=C(C3=NC=C(C(OCOC(C)=O)=O)O3)O2)C=C1OCCOC(C=C(C)C=C4)=C4N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
InChi Code
InChI=1S/C44H47N3O24/c1-25-7-8-32(46(16-39(53)65-20-60-26(2)48)17-40(54)66-21-61-27(3)49)35(11-25)58-9-10-59-36-12-31-13-37(43-45-15-38(71-43)44(57)69-24-64-30(6)52)70-34(31)14-33(36)47(18-41(55)67-22-62-28(4)50)19-42(56)68-23-63-29(5)51/h7-8,11-15H,9-10,16-24H2,1-6H3
InChi Key
VPSRLGDRGCKUTK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $162

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    Product Description

    Fura-2 AM is a membrane permeable, UV light-excitable form of Fura-2 (Item Nos. 19531 | 20414).1 It crosses cell membranes and is converted to Fura-2 via cellular esterases.2 Fura-2 is a ratiometric fluorescent calcium indicator that can be used to detect calcium in cells.3 It is a pentacarboxylate that displays excitation maxima of 340 and 380 nm at high and low calcium concentrations, respectively, when the emission is fixed at 510 nm, enabling determination of ratiometric measurements of calcium influx in live cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sabnis, R.W. Handbook of biological dyes and stains: Synthesis and industrial applications. (2010).

    2. Grynkiewicz, G., Poenie, M., and Tsien, R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. The Journal of Biological Chemisty 260(6), 3440-3450 (1985).

    3. Kong, S.K., and Lee, C.Y. The use of fura 2 for measurement of free calcium concentration. Biochem. Mol. Biol. Ed. 23(2), 97-98 (1995).