A histamine H1 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Meclizine (hydrochloride)

Item No. 14615

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine, hydrochloride
CAS Number
36236-67-6
Synonyms
  • Meclozine
  • NSC 28728
Molecular Formula
C25H27ClN2 • XHCl
Formula Weight
391.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.1 mg/mlEthanol: 0.1 mg/ml
λmax
229 nm
SMILES
CC1=CC=CC(CN(CC2)CCN2C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4)=C1.Cl.Cl
InChi Code
InChI=1S/C25H27ClN2.ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;/h2-13,18,25H,14-17,19H2,1H3;1H
InChi Key
GJNMJOHYRWHJQB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $103

    Add

    10 mg

    $132

    Add

    25 mg

    $303

    Add

    50 mg

    $553

    Add
    Product Description

    Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).1 Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.2 Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tran, V.T., Chang, R.S.L., and Snyder, S.H. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc. Natl. Acad. Sci. USA 75(12), 6290-6294 (1978).

    2. Pasquale, C.P., e Silva, P.M., Lima, M.C., et al. Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. Eur. J. Pharmacol. 223(1), 9-14 (1992).