A selective, cell-permeable EZH2 inhibitor
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UNC1999

Item No. 14621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)Epigenetic Chemical Probe Guide (PDF)
Technical Information
Formal Name
N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-1H-indazole-4-carboxamide
CAS Number
1431612-23-5
Molecular Formula
C33H43N7O2
Formula Weight
569.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlEthanol: 0.1 mg/ml
λmax
231, 282, 313 nm
SMILES
CC(C)N1C2=CC(C3=CC=C(N4CCN(C(C)C)CC4)N=C3)=CC(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C2C=N1
InChi Code
InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChi Key
DPJNKUOXBZSZAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $135

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    50 mg

    $502

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    Product Description

    UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other histone methytranferases.1 UNC1999 has been shown to inhibit H3K27 methylation in MCF10A cells with an IC50 value of 124 nM.1 For more information on UNC1999 please visit the Structural Genomics Consortium (SGC). The negative control, UNC2400, for UNC1999 is also available exclusively through the SGC. You can submit a request to receive the negative control here.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konze, K.D., Ma, A., Li, F., et al. An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem. Biol. 8(6), 1324-1334 (2013).