Topoisomerase IIα inhibitor and intracellular ion chelator
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Isomer(s)
45123Razoxane
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Dexrazoxane

Item No. 14632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-2,6-piperazinedione
CAS Number
24584-09-6
Synonyms
  • ICRF 187
  • NSC 169780
Molecular Formula
C11H16N4O4
Formula Weight
268.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 0.25 mg/ml
SMILES
O=C(N1)CN(C[C@H](C)N2CC(NC(C2)=O)=O)CC1=O
InChi Code
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChi Key
BMKDZUISNHGIBY-ZETCQYMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $53

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    25 mg

    $86

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    50 mg

    $153

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    Product Description

    Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.1 Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.2 Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, T., Deng, S., Metzger, A., et al. Topoisomerase IIα-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin. Mol. Cancer Ther. 8(5), 1075-1085 (2009).

    2. Kurz, T., Grant, D., Andersson, R.G.G., et al. Effects of MnDPDP and ICRF-187 on doxorubicin-induced cardiotoxicity and anticancer activity. Transl. Oncol. 5(4), 252-259 (2012).

    3. Junjing, Z., Yan, Z., and Baolu, Z. Scavenging effects of dexrazoxane on free radicals. J. Clin. Biochem. Nutr. 47(3), 238-245 (2010).