A racemic mixture of dexrazoxane and levrazoxane
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Isomer(s)
14632Dexrazoxane
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Razoxane

Item No. 45123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
CAS Number
21416-67-1
Synonyms
  • ICI 59118
  • ICRF 159
  • NSC 129943
Molecular Formula
C11H16N4O4
Formula Weight
268.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C1NC(CN(CC(C)N2CC(NC(C2)=O)=O)C1)=O
InChi Code
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
InChi Key
BMKDZUISNHGIBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

    $120

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    25 mg

    $252

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    50 mg

    $410

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    Cayman Chemical
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    Product Description

    Razoxane is a racemic mixture of dexrazoxane (Item No. 14632) and levrazoxane.1 Unlike dexrazoxane, razoxane inhibits topoisomerase II-α (TOP2A) and TOP2B only weakly (IC50s = 301 and 505 µM, respectively). Razoxane slows tumor growth, normalizes intratumoral vasculature, and prevents metastases in murine Lewis lung carcinoma models when administered at a dose of 30 mg/kg.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jirkovská, A., Karabanovich, G., Kubeš, J., et al. Structure-activity relationship study of dexrazoxane analogues reveals ICRF-193 as the most potent bisdioxopiperazine against anthracycline toxicity to cardiomyocytes due to its strong topoisomerase IIβ interactions. J. Med. Chem. 64(7), 3997-4019 (2021).

    2. Le Serve, A.W., and Hellmann, K. Metastases and the normalization of tumour blood vessels by ICRF 159: A new type of drug action. Br. Med. J. 1(5800), 597-601 (1972).

    3. Salsbury, A.J., Burrage, K., and Hellmann, K. Histological analysis of the antimetastatic effect of (±)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. Cancer Res. 34(4), 843-849 (1974).

    4. Hellmann, K. Dynamics of tumour angiogenesis: Effect of razoxane-induced growth rate slowdown. Clin. Exp. Metastasis 20(2), 95-102 (2003).