A DNA topoisomerase I inhibitor
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(S)-10-hydroxy-Camptothecin

Item No. 14635

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number
19685-09-7
Synonyms
  • ChEMBL 273862
  • NSC 107124
Molecular Formula
C20H16N2O5
Formula Weight
364.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
222, 267, 330, 383 nm
SMILES
O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3)C3=C4)=C4C5)N5C2=O
InChi Code
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChi Key
HAWSQZCWOQZXHI-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound.1 (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM).1 In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, P., Xia, L., Zhao, J., et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol. Pharm. Bull. 35(8), 1295-1299 (2012).

    2. Zhang, X.W., Jiang, J.F., and Xu, B. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol. Sin. 21(4), 364-368 (2000).