An alkaloid with DNA topoisomerase I inhibitory and anticancer activities
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Isomer(s)
14635(S)-10-hydroxy-Camptothecin
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10-hydroxy Camptothecin

Item No. 46297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number
64439-81-2
Synonyms
  • DL-10-hydroxy Camptothecin
  • 10-HCPT
Molecular Formula
C20H16N2O5
Formula Weight
364.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
OC1=CC2=CC(CN3C4=CC(C5(O)CC)=C(COC5=O)C3=O)=C4N=C2C=C1
InChi Code
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChi Key
HAWSQZCWOQZXHI-UHFFFAOYSA-N
Origin
Plant/Camptotheca acuminata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $49

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    50 mg

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    100 mg

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    250 mg

    $172

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    Product Description

    10-hydroxy Camptothecin is an alkaloid originally isolated from C. acuminata that has DNA topoisomerase I inhibitory and anticancer activities.1,2 It inhibits DNA topoisomerase I (IC50 = 1 µM), reduces the proliferation of L1210 leukemia cells (IC50 = 18 nM), and increases survival by 78% in an L1210 murine leukemia model at 21 µmol/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wani, M.C., and Wall, M.E. Plant antitumor agents. II. Structure of two new alkaloids from Camptotheca acuminata. The Journal of Organic Chemistry 34(5), 1364–1367 (1968).

    2. Kingsbury, W.D., Boehm, J.C., Jakas, D.R., et al. Synthesis of water-soluble (aminoalkyl)camptothecin analogues: Inhibition of topoisomerase I and antitumor activity. J. Med. Chem. 34(1), 98-107 (1991).