An inhibitor of hexokinase
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Lonidamine

Item No. 14640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
CAS Number
50264-69-2
Synonyms
  • AF 1890
  • DICA
  • Diclondazolic Acid
Molecular Formula
C15H10Cl2N2O2
Formula Weight
321.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 1.7 mg/ml
λmax
298 nm
SMILES
OC(C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C31)=O
InChi Code
InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
InChi Key
WDRYRZXSPDWGEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 μM, respectively.1 A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Floridi, A., Paggi, M.G., D'Arti, S., et al. Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Cancer Res. 41(11), 4661-4666 (1981).

    2. Brawer, M.K. Lonidamine: Basic science and rationale for treatment of prostatic proliferative disorders. Rev.Urol. 7 (Suppl.7), 21-26 (2005).

    3. Marrache, S., and Dhar, S. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc. Natl. Acad. Sci. USA 109(40), 16288-16293 (2012).

    4. Miccoli, L., Poirson-Bichat, F., Sureau, F., et al. Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. J. Natl. Cancer Inst. 90(18), 1400-1406 (1998).