A selective LPA2 receptor antagonist
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H2L5186303

Item No. 14663

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z,Z)-4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
CAS Number
139262-76-3
Molecular Formula
C26H20N2O8
Formula Weight
488.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 15 mg/ml
λmax
298 nm
SMILES
O=C(/C=C\C(O)=O)NC(C=C1)=CC=C1OC2=CC(OC3=CC=C(NC(/C=C\C(O)=O)=O)C=C3)=CC=C2
InChi Code
InChI=1S/C26H20N2O8/c29-23(12-14-25(31)32)27-17-4-8-19(9-5-17)35-21-2-1-3-22(16-21)36-20-10-6-18(7-11-20)28-24(30)13-15-26(33)34/h1-16H,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/b14-12-,15-13-
InChi Key
HZFPOTBCYPWQSH-DZDAAMPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $139

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    Product Description

    H2L5186303 is a selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 9 nM in a LPA-elicited calcium mobilization assay).1 It inhibits LPA1 and LPA3 at much higher concentrations (IC50s = 27,354 and 4,504 nM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fells, J.I., Tsukahara, R., Liu, J., et al. Structure-based drug design identifies novel LPA3 antagonists. Bioorg. Med. Chem. 17(21), 7457-7464 (2009).