A selective inhibitor of GSK3β
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GSK3β Inhibitor VIII

Item No. 14704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-urea
CAS Number
487021-52-3
Synonyms
  • AR 014418
  • AR 0133418
  • Glycogen Synthase Kinase 3β Inhibitor VIII
  • SN 4521
Molecular Formula
C12H12N4O4S
Formula Weight
308.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
λmax
226, 275, 348, 353 nm
SMILES
O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2
InChi Code
InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
InChi Key
YAEMHJKFIIIULI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $149

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    50 mg

    $622

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    Product Description

    GSK3β inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM).1 It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM).1 GSK3β inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhat, R., Xue, Y., Berg, S., et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. The Journal of Biological Chemisty 278(46), 45937-45945 (2003).