A DPP-4 inhibitor
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Vildagliptin

Item No. 14705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile
CAS Number
274901-16-5
Synonyms
  • LAF237
  • NVP-LAF237
Molecular Formula
C17H25N3O2
Formula Weight
303.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CN[C@@]1(CC(C2)C3)CC3C[C@]2(O)C1)N4[C@H](C#N)CCC4
InChi Code
InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14?,16-,17-
InChi Key
SYOKIDBDQMKNDQ-QWJLZPNVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $32

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    50 mg

    $88

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    100 mg

    $145

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    1 g

    $319

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Vildagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.003 µM).1 It is selective for DPP-4 over DPP-2, DPP-8, and DPP-9 (Kis = >500, 0.81, and 0.095 µM, respectively). Vildagliptin (3 mg/kg) decreases plasma glucose levels and increases plasma insulin levels during an oral glucose challenge in Zucker fa/fa rats.2 It prevents increases in liver triglyceride and thiobarbituric acid reactive substance (TBARS) levels in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a high-cholesterol diet.3 Formulations containing vildagliptin have been used in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ikuma, Y., Hochigai, H., Kimura, H., et al. Discovery of 3H-imidazol[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg. Med. Chem. 20(19), 5864-5883 (2012).

    2. Burkey, B.F., Li, X., Bolognese, L., et al. Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats. J. Pharmacol. Exp. Ther. 315(2), 688-695 (2005).

    3. Kamal, S.M. Anti-oxidant and anti-inflammatory effects of vildagliptin in non-alcoholic fatty liver disease of mice. Int. J. Med. Nano Res. 1(1), 1-5 (2014).