Selective antagonist of PAR2
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FSLLRY-amide

Item No. 14709

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide
CAS Number
245329-02-6
Molecular Formula
C39H60N10O8
Formula Weight
797.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 0.5 mg/mlDMSO: 20 mg/ml
λmax
280 nm
SMILES
O=C(N[C@H](C(N)=O)CC1=CC=C(O)C=C1)[C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](N)CC2=CC=CC=C2)=O)=O)=O)=O
InChi Code
InChI=1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2
InChi Key
KMSCNWHRNILNRJ-JNRWAQIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $98

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    5 mg

    $266

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    10 mg

    $435

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    25 mg

    $842

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    Product Description

    FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2 (Item No. 16723).1 It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein.1 It can be used to study PAR2 action in cells and in animals.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Al-Ani, B., Saifeddine, M., Wijesuriya, S.J., et al. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J. Pharmacol. Exp. Ther. 300(2), 702-708 (2002).

    2. McLarty, J.L., Meléndez, G.C., Brower, G.L., et al. Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58(2), 264-270 (2011).

    3. Chen, Y., Yang, C., and Wang, Z.J. Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain. Neuroscience 193, 440-451 (2011).