A natural sesquiterpene lactone
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Costunolide

Item No. 14743

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3aS,4,5,8,9,11aR-hexahydro-6E,10E-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
CAS Number
553-21-9
Synonyms
  • Costus lactone
  • Melampolide
  • NSC 106404
Molecular Formula
C15H20O2
Formula Weight
232.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.6 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 0.1 mg/ml
SMILES
C/C1=C\[C@@H](OC(C2=C)=O)[C@H]2CC/C(C)=C\CC1
InChi Code
InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5-,11-9+/t13-,14+/m0/s1
InChi Key
HRYLQFBHBWLLLL-GRFSRWIASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $63

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    10 mg

    $109

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    25 mg

    $234

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    Cayman Chemical
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    Product Description

    Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines.1,2,3 Costunolide inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM).4,5 It also inhibits telomerase activity in NALM-6 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanno, S.I., Kitajima, Y., Kakuta, M., et al. Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells. Biol. Pharm. Bull. 31(5), 1024-1028 (2008).

    2. Liu, C.Y., Chang, H.S., Chen, I.S., et al. Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat. Oncol. 6, 56 (2011).

    3. Lohberger, B., Rinner, B., Stuendl, N., et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One 8(6), e66300 (2013).

    4. Kim, J.H., Yang, Y.I., Lee, K.T., et al. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biol. Pharm. Bull. 34(4), 580-585 (2011).

    5. Butturini, E., Cavalieri, E., Carcereri de Prati, A., et al. Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation. PLoS One 6(5), e20174 (2011).