An inhibitor of casein kinase 2
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TBCA

Item No. 14831

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid
CAS Number
934358-00-6
Synonyms
  • Casein Kinase II Inhibitor III
  • Tetrabromocinnamic Acid
Molecular Formula
C9H4Br4O2
Formula Weight
463.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
237, 278 nm
SMILES
BrC1=C(Br)C(Br)=C(Br)C=C1/C=C/C(O)=O
InChi Code
InChI=1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
InChi Key
SVJQCVOKYJWUBC-OWOJBTEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $534

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    Product Description

    Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.1,2 TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases.3 It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.3 TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. López-Ramos, M., Prudent, R., Moucadel, V., et al. New potent dual inhibitors of CK2 and Pim kinases: Discovery and structural insights. The FASEB Journal 24(9), 3171-3185 (2010).

    2. Pagano, M.A., Cesaro, L., Meggio, F., et al. Protein kinase CK2: A newcomer in the 'druggable kinome'. Biochem. Soc. Trans. 34(Pt 6), 1303-1306 (2006).

    3. Pagano, M.A., Poletto, G., Di Maira, G., et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem 8(1), 129-139 (2007).

    4. Ryu, S.Y., and Kim, S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. Eur. J. Pharmacol. 720(1-3), 391-400 (2013).

    5. Kim, H., Choi, K., Kang, H., et al. Identification of a novel function of CX-4945 as a splicing regulator. PLoS One 9(4), e94978 (2014).