A PPARα and PPARγ agonist
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Active Metabolite(s)
19080Gemfibrozil 1-O-β-Glucuronide
Labeled Version(s)
31915Gemfibrozil-d6
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Gemfibrozil

Item No. 14835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
CAS Number
25812-30-0
Synonyms
  • CI-719
Molecular Formula
C15H22O3
Formula Weight
250.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 16 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
219, 275, 281 nm
SMILES
CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1
InChi Code
InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChi Key
HEMJJKBWTPKOJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $70

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    10 g

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    25 g

    $209

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).1 In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.2 Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.3 Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, N.J., Lee, K.O., Koo, B.W., et al. Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists. Bioorg. Med. Chem. Lett. 17(13), 3595-3598 (2007).

    2. Solanki, Y.B., and Jain, S.M. Antihyperlipidemic activity of Clitoria ternatea and Vigna mungo in rats. Pharm. Biol. 48(8), 915-923 (2010).

    3. Calkin, A.C., Cooper, M.E., Jandeleit-Dahm, K.A., et al. Gemfibrozil decreases atherosclerosis in experimental diabetes in association with a reduction in oxidative stress and inflammation. Diabetologia 49(4), 766-774 (2006).