An alkylating antineoplastic agent
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Labeled Version(s)
23096Busulfan-d8
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Busulfan

Item No. 14843

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dimethanesulfonate 1,4-butanediol
CAS Number
55-98-1
Synonyms
  • Busulphan
  • Mielosan
  • Milecitan
  • Myeloleukon
  • Mylecytan
  • Myleran
  • NCI C01592
  • NSC 750
Molecular Formula
C6H14O6S2
Formula Weight
246.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16.7 mg/mlDMSO: 16.7 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
CS(OCCCCOS(C)(=O)=O)(=O)=O
InChi Code
InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChi Key
COVZYZSDYWQREU-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $54

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    250 g

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    Cayman Chemical
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    Product Description

    Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.1 It forms both intra- and interstrand crosslinks on DNA.2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Appelbaum, F.R. Optimizing the conditioning regimen for acute myeloid leukemia. Best Pract. Res. Clin. Haematol. 22(4), 543-550 (2009).

    2. Iwamoto, T., Hiraku, Y., Oikawa, S., et al. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 95(5), 454-458 (2004).

    3. Ponti, M., Souhami, R.L., Fox, B.W., et al. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates. Br. J. Cancer 63(5), 743-747 (1991).

    4. Copelan, E.A., and Deeg, H.J. Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation. Blood 80(7), 1648-1658 (1992).