An internal standard for the quantification of busulfan
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Unlabeled Version(s)
14843Busulfan
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Busulfan-d8

Item No. 23096

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-butane-1,1,2,2,3,3,4,4-d8-diol, dimethanesulfonate
CAS Number
116653-28-2
Synonyms
  • Busulphan-d8
  • Mielosan-d8
  • Milecitan-d8
  • Myeloleukon-d8
  • Mylecytan-d8
  • Myleran-d8
Molecular Formula
C6H6D8O6S2
Formula Weight
254.3
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16.7 mg/mlDMSO: 16.7 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
256 nm
SMILES
CS(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OS(C)(=O)=O)(=O)=O
InChi Code
InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3/i3D2,4D2,5D2,6D2
InChi Key
COVZYZSDYWQREU-SQUIKQQTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Busulfan-d8 is intended for use as an internal standard for the quantification of busulfan (Item No. 14843) by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.1 It forms both intra- and interstrand crosslinks on DNA.2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Appelbaum, F.R. Optimizing the conditioning regimen for acute myeloid leukemia. Best Pract. Res. Clin. Haematol. 22(4), 543-550 (2009).

    2. Iwamoto, T., Hiraku, Y., Oikawa, S., et al. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 95(5), 454-458 (2004).

    3. Ponti, M., Souhami, R.L., Fox, B.W., et al. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates. Br. J. Cancer 63(5), 743-747 (1991).

    4. Copelan, E.A., and Deeg, H.J. Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation. Blood 80(7), 1648-1658 (1992).